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ORIGINAL ARTICLE
Year : 2020  |  Volume : 4  |  Issue : 1  |  Page : 1-3

Research on the role of toll-like receptor 2 and toll-like receptor 4 and its signal pathway in the pathogenesis of primary gout arthritis


1 Department of Rheumatology and Immunology, College of Educational Science, Xinjiang Normal University, Urumqi, China
2 Department of Endocrinology, College of Educational Science, Xinjiang Normal University, Urumqi, China
3 Department of Emergency, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, China
4 Department of Psychological, College of Educational Science, Xinjiang Normal University, Urumqi, China

Correspondence Address:
Dr. R J Cui
Department of Rheumatology and Immunology, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/MTSP.MTSP_5_19

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Objectives: The study objective was to research the role of toll-like receptor (TLR) 2 and TLR 4 and its signal pathway in the pathogenesis of primary gout arthritis. Methods: Seventy-two patients with primary gout arthritis were selected as the experimental group and 72 healthy controls were selected as the control group. The real-time fluorescence quantitative polymerase chain reaction method was used for testing. Blood uric acid (UA) level, interleukin (IL) IL-1β level, and TLR4 and TLR2 were observed in the two groups. Results: Compared with the control group, the levels of UA, IL-1β, and TLR4 in the observation group were significantly higher than those in the control group, and there was a statistically significant difference between the two groups (P < 0.05). There was no positive correlation between plasma UA level, IL-1β level, and TLR2 (P > 0.05). There was no correlation between TLR2 and serum UA level and IL-1β level in the control group (P > 0.05). Conclusions: TLR4 and IL-1β signaling acceleration is closely related to gouty arthritis. When the TLR4 signal pathway is activated, the UA salt crystal changes in the patient's body.


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