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ORIGINAL ARTICLE
Year : 2019  |  Volume : 3  |  Issue : 1  |  Page : 23-25

The study of differentially expressed serum protein in patients with different traditional chinese medicine syndromes of knee osteoarthritis


1 Department of Orthopedics, Affiliated TCM Hospital of Xinjiang Medical University, Urumqi, China
2 Departments of Orthopaedics, Spine Surgery and Joint Surgery, The University of Tokyo Hospital, 7 Chome-3-1 Hongo, Bunkyo City, Tokyo 113-8655, Japan

Correspondence Address:
Dr. Y B Zhou
Department of Orthopedics, Affiliated TCM Hospital of Xinjiang Medical University, Urumqi
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/MTSP.MTSP_10_19

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Objectives: To study the distribution characteristics of patients with knee osteoarthritis (KOA) of different traditional Chinese medicine (TCM) syndromes and to reveal the differences from the perspectives of expressions of serum inflammatory indicators. Methods: One hundred and thirty-four patients with KOA treated in our hospital from January 2013 to March 2016 and referring to TCM syndrome types were included in the study and were divided into three types: Yin deficiency in kidney and liver\tendon and vesselstasissyndrome,s pleen and kidney deficiency\ wet injection the osteomere syndrome, kidney Yang deficiency and weak\phlegm stasis syndrome; 24 healthy persons who took physical examination in our hospital were selected as the normal control group. Patients' blood was collected in the morning as the blood samples, and the levels of inflammatory factors (5-TH, interleukin-6 [IL-6], and tumor necrosis factor-α [TNF-α]) were measured in serum. Results: The most common TCM syndrome of KOAin the clinical trialsis Yin deficiency in kidney and liver\tendon and vesselstasissyndrome, the percents of spleen and kidney deficiency\wet injection the osteomere syndrome and kidney Yang deficiency and weak\phlegm stasissyndrome are near, the former is slightly higher than the latter by 3.97%. The levels of IL-6 and TNF-α in the three groups were significantly higher than those in the normal control group, whereas the 5-TH level was significantly lower in the three groups than that in the normal control group (P < 0.05). The levels of IL-6 and TNF-α in the kidney Yang deficiency and weak\phlegm stasis syndrome group were significantly higher than the next two TCM syndrome groups (P < 0.05), whereas the 5-TH level in the kidney Yang deficiency and weak\phlegm stasis syndrome group was significantly lower than the next two TCM syndrome groups (P < 0.05). Conclusions: Yin deficiency in kidney and liver\tendon and vessel stasis syndrome is the most common TCM syndrome of KOA in the clinical trials. The levels of inflammatory factors (5 TH, IL 6, and TNF α) in serum had a close relationship with KOA. In terms of the perspectives of expressions of serum inflammatory indicators, the most serious TCM syndrome of KOA is kidney Yang deficiency and weak\phlegm stasis syndrome.


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